There's a lot of different situations. Most recently I was running mics for an interview discussion on a corporate gig. Very strange room shape, and difficult to place speakers:
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There were two seats up front for the presenters who were each wearing lav mics. The speaker (bose compacts) closest to them was turned about 65 degrees back toward the audience trying to get the output of the speaker away from the mics. The second speaker was along the same wall near the back of the space and was far enough back that it wasn't bleeding into the mics.
This place is closed for events now, but another example of a very challenging room that we've had to work in for ceremony is this one:
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It was reverb city in there. Not a single surface soaked anything up, just marble and stone.
Another nightmare:
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Super long thin room. Guest chairs basically all the way up the sides with nowhere good to place a speaker in the space that isn't too close to the mics. Another example with all hard surfaces in the room. Very, very challenging. I've tried to do one at the front (pointed directly away from the speakers and set up in front of the people talking) but it caused major problems, so I'm basically stuck putting speakers at the back of the audience.
We deal with a bunch of really pretty, but very awkward spaces from a sound perspective.