Depends on what you want to do...
If you want to use that Reatune trick I showed you the other night, then it shouldn't be a problem. Basically if your mixer board has a "Effects Processor" or "Preamp" output, it shouldn't be a problem, just hook those up to your sound cards input, then hook the sound cards output up to the amp.
Of course, if you want to go completely crazy like I do, route your mics and BGM into seperate outputs, then you're gonna need that 1616.
