It seems like some have had chips inserted for a while, and need a reboot
Is it the time to market?
- Thread starter Jeff Romard
- Start date
It is the first "MRNA" vaccine that will be produced, and used by people.
Horizon Magazine
3. Most of what we know about mRNA vaccines comes from work on cancer
Most work on using mRNA to provoke an immune response has so far been focused on cancer, with tumour mRNA being used to help people’s immune systems recognise and respond to the proteins produced by their specific tumours. ‘This technology was very good for the oncology field, because you can develop patient-specific vaccines because every tumour is different,’ said Prof. Bekeredjian-Ding.
Using tumour mRNA in this way activates the body’s T-cells – the part of the acquired immune system that kills cells, which is useful to destroy tumours. It could be important for coronavirus, too. ‘In viral infections, often we know that there is a need for a strong T-cell response because viruses like to hide in cells,’ said Prof. Bekeredjian-Ding. ‘There is a certain hope that, especially in this setting, this could really work … and thereby eliminate … the infected cells from the body.’
But to combat a virus such as SARS-CoV-2, it is likely that a different part of the acquired immune system also needs to be activated – the B cells, which produce antibodies that mark the virus out for destruction by the body. ‘And there is little experience with this (apart from animal infection models), because for the tumour model this was not that relevant.’
4. There are a lot of unknowns
Because mRNA vaccines are only now beginning to be tested in humans, there are a lot of fairly basic unknowns which can only be answered through human trials. ‘What is really the current challenge, I think, is to understand whether these vaccines will really be able to mount a sufficiently protective immune response in the human and to understand, for example, which quantities of mRNA will be needed to do this,’ said Prof. Bekeredjian-Ding.
Other outstanding questions include whether the proteins that have been chosen for the vaccine are the right ones to prevent a coronavirus infection in the body, how targeted the immune response is to this particular coronavirus, how long any immunity would last, and whether it causes side-effects such as increased inflammatory responses like redness and swelling or, in the worst case, aggravates disease.
‘It's a very unique way of making a vaccine and, so far, no (such) vaccine has been licenced for infectious disease.’
It is the first "MRNA" vaccine that will be produced, and used by people.
Horizon Magazine
horizon-magazine.eu
3. Most of what we know about mRNA vaccines comes from work on cancer
Most work on using mRNA to provoke an immune response has so far been focused on cancer, with tumour mRNA being used to help people’s immune systems recognise and respond to the proteins produced by their specific tumours. ‘This technology was very good for the oncology field, because you can develop patient-specific vaccines because every tumour is different,’ said Prof. Bekeredjian-Ding.
Using tumour mRNA in this way activates the body’s T-cells – the part of the acquired immune system that kills cells, which is useful to destroy tumours. It could be important for coronavirus, too. ‘In viral infections, often we know that there is a need for a strong T-cell response because viruses like to hide in cells,’ said Prof. Bekeredjian-Ding. ‘There is a certain hope that, especially in this setting, this could really work … and thereby eliminate … the infected cells from the body.’
But to combat a virus such as SARS-CoV-2, it is likely that a different part of the acquired immune system also needs to be activated – the B cells, which produce antibodies that mark the virus out for destruction by the body. ‘And there is little experience with this (apart from animal infection models), because for the tumour model this was not that relevant.’
4. There are a lot of unknowns
Because mRNA vaccines are only now beginning to be tested in humans, there are a lot of fairly basic unknowns which can only be answered through human trials. ‘What is really the current challenge, I think, is to understand whether these vaccines will really be able to mount a sufficiently protective immune response in the human and to understand, for example, which quantities of mRNA will be needed to do this,’ said Prof. Bekeredjian-Ding.
Other outstanding questions include whether the proteins that have been chosen for the vaccine are the right ones to prevent a coronavirus infection in the body, how targeted the immune response is to this particular coronavirus, how long any immunity would last, and whether it causes side-effects such as increased inflammatory responses like redness and swelling or, in the worst case, aggravates disease.
‘It's a very unique way of making a vaccine and, so far, no (such) vaccine has been licenced for infectious disease.’
Well what we read is quite different perhaps different vaccines?
The point is you said it takes 7 years to develop a vaccine. There is a flu vaccine every year each strain is different and the vaccine changes each year to suit the strain. How is that possible?
The main reason it takes so long is money and manpower. This one has our full attention because it is costing people who have money money. Billions have been dropped in to this and every country capable is on board
I'm not saying there won't be problems sure there will every vaccine has the potential to cause reactions sometimes fatal. There reactions are quite small for the most part though. For those who won't take it because they don't know what's in it I sure hope you don't eat Hotdogs or Poptarts
The vaccine is real, and will be distributed widely, quickly.
What's different this time?
WHOLE world and EVERYONE in it, all ages, need a vaccine.
No limit on the money invested to make it happen.
EVERYONE is working on it, sharing info - no patents or proprietary info.
It will be free for everyone (in the US at least) - so no need to 'sell' it - every dose is already 'sold'.
Corona virus is a FLU virus, so not really the first of it's kind.
The difference/challenge will be, according to a friend that works for Aetna (up the chain a bit) is EVERYONE will be tested BEFORE getting the vaccine - if you have the antibodies no need to take the vaccine.
If not, then it's a 2 dose situation, 2 weeks apart.
The military/national guard will be involved in distribution, but CVS/RiteAid/Walmart etc will be doing the shots - it's gonna be everywhere.
There are 2 (or now i'm hearing 3) vaccines. Of the 2, one needs to be stored at -92F so that creates a distribution challenge. the other just needs regular refrigeration.
What's different this time?
WHOLE world and EVERYONE in it, all ages, need a vaccine.
No limit on the money invested to make it happen.
EVERYONE is working on it, sharing info - no patents or proprietary info.
It will be free for everyone (in the US at least) - so no need to 'sell' it - every dose is already 'sold'.
Corona virus is a FLU virus, so not really the first of it's kind.
The difference/challenge will be, according to a friend that works for Aetna (up the chain a bit) is EVERYONE will be tested BEFORE getting the vaccine - if you have the antibodies no need to take the vaccine.
If not, then it's a 2 dose situation, 2 weeks apart.
The military/national guard will be involved in distribution, but CVS/RiteAid/Walmart etc will be doing the shots - it's gonna be everywhere.
There are 2 (or now i'm hearing 3) vaccines. Of the 2, one needs to be stored at -92F so that creates a distribution challenge. the other just needs regular refrigeration.
Not unless you have a specific and highly desirable solution to the Social Distancing problem.
Even if you could do events right now, how would you justify the liability inherent with: contact tracing, political backlash, bad public relations, and actual threats of retaliation ?
In my area, lock down is projected to continue for another 6 - 12 months, with even stricter measures. (The "Dark Winter.") We are now in Month 10 or our "15 days to flatten the curve.)
Right now - 37% of small businesses in MA have closed permanently (they will never be coming back.) That figure does not include the many self-employed service people (like DJs) who despite the lack of a retail storefront - are no longer able to work, and could remain that way for years under a government policy or social order known as the "new normal." There are blocks in my own city that in February were bustling with business, where no retail space for rent was left available - that are today boarded up and vacant.
In a world where people are divided into arbitrary classes, deemed "non-essential," not allowed to go to church, or even to sing; and prohibited from gathering in any group larger than their household members - what possibility is there to celebrate anything in any measure ? Who wants to waste money on such a freakish reality ?
Where there are such elites who can afford such absurdity - do you really want to be a part of that hypocrisy ? Personally, I am not willing to support the dystopian uplighting and party whims of the self-absorbed while millions of people's civil and human rights are being denied.
I'm not marketing because many of my recurring customers are government, non-profits, or beneficiaries of the same. My message is a simple one:
If I'm not free to work for everyone - I'm not willing to work for you.
Last edited:
In the past week or so I've booked a wedding (oct 21), a NYE party and just yesterday a christmas party at a bar.
So there ARE customers out there. I don' t know about the bar, as in how they found me and why once I quoted them a price they called around (said they would do that and get back to me) and in 3 hours called back to book. I nearly doubled my normal bar gig price.
SO...was I cheapest? Only one available, only one willing to do the gig? I don't know.
It's weird out there and the people in charge are STUPID as hell.
A friend in the photo biz got this from State of Ohio: They will have wrestling, and therefore wrestling pictures - AS LONG AS THE KIDS DON"T SHAKE HANDS IT"S OK TO WRESTLE.
WTF?
So there ARE customers out there. I don' t know about the bar, as in how they found me and why once I quoted them a price they called around (said they would do that and get back to me) and in 3 hours called back to book. I nearly doubled my normal bar gig price.
SO...was I cheapest? Only one available, only one willing to do the gig? I don't know.
It's weird out there and the people in charge are STUPID as hell.
A friend in the photo biz got this from State of Ohio: They will have wrestling, and therefore wrestling pictures - AS LONG AS THE KIDS DON"T SHAKE HANDS IT"S OK TO WRESTLE.
WTF?
I think you have to realize that in most major markets the landscape is significantly different.
CA is under a "stay at home order." That means the government has ordered people NOT to leave their home for ANY social reason. Whether people abide by that order is irrelevant because it is WE as business owners who are most easily prosecuted by both the visible and documented evidence. DJs are "non-essetial" by every metric used and therefore the inherent liability in contact tracing adds yet another layer of risk.
MA prohibits any indoor gathering of more than 10 people, outdoor gatherings of 25 people, and promotes a full stay at home no social gathering of any kind position - falling just short of an executive order.
All of these things are unconstitutional at both the state and federal level occurring simultaneously with a presidential election that is statistically implausible. That is - the orders being enforced are not written anywhere in our statutes, they simply don't exist in current law beyond a 45 day emergency period. The statutes that are written in our law are no longer being upheld, and the protections granted by our constitutions are not being defended or in many cases even acknowledged. We cannot conduct business in a nation that has no legal certainty and no guarantee of any civil liberty. We are all presently as vulnerable as a Jewish Bakery Shop in 1938 Germany. We are living in a modern day " Kristallnacht" posed as a woke social justice movement. It took Germany 5 years to move from a boycott of Jewish businesses to an outright physical attack and destruction. In a modern high-tech driven U.S. it won't take anywhere near that long juts ask anyone who lives in Portland, OR.
The defiance that is occurring in places such as Staten Island is not really about whether you can go out for a beer of dinner, It''s about families with children being selectively sentenced to a slow death by systematic economic oppression at the hands of their own government. I'll say it again - because we all really need to think about this:
...families with children being selectively sentenced to a slow death by systematic economic oppression at the hands of their own government.
We are now a full year into this so-called pandemic (blood collected across the nation in Red Cross Blood drives early last December tests positive for Covid from coast to coast showing the virus had already crossed the nation months before we were told.) Yet, people still want to believe this a temporary thing - even while describing it with permanent language like "the new normal." This is not about safety - it's about leveraging a Health Scare to consolidate power and over-throw a democracy, and it is succeeding.
Last edited:
It may be worse, the lying, the false hope...
I've read that the covid has mutated into 2, or probably 3 strains. Some deadler that others, some spread faster/easier than others.
The flu vaccine works on ONE or MAYBE 2 strains...they need a new vaccine each year as the flu virus mutates. It's also why there is cure for the common cold, also a corona virus that mutates very quickly.
So...on the WTAE/ABC affiliate the morning (this being the home of the world's best football team, the Steelers) they were talking football - specifically the Ravens...and how it had been reported that there were FOUR DIFFERENT STRAINS OF THE COVID 19 IN THEIR LOCKER ROOM/STAFF LAST WEEK.
Yes FOUR.
SO....is this vaccine gonna work? How is it working on 4 mutations? How is it 90% effective when NO flu vaccine is that good?
And add to this, on CBS news today was a story about 102 year old woman in NYC that has recoverd from COVID TWICE - so that means OBVIOUSLY there are questions about immunity...do you get it at all? FOr one strain only? It doesn't last?
I guess we all need to go into some form of online shopping/delivery....seems that will be a growth area for some time to come.
Surprisingly PA was VERY proactive, um, over re-active in the beginning of this - the latest surge (12,000 plus per day testing positive, testing rates of 37% postitive (goal is what, 5%?) and NOTHING from teh state health or governor. No lockdowns, no reduced capacity, etc.
And Ohio's infinite idiots say yes, school wresting may happen - AS LONG AS THE KIDS DON"T SHAKE HANDS it will be fine. WTF?
With bright minds saying things like that is it any wonder we have no clue what the reality is?
I've read that the covid has mutated into 2, or probably 3 strains. Some deadler that others, some spread faster/easier than others.
The flu vaccine works on ONE or MAYBE 2 strains...they need a new vaccine each year as the flu virus mutates. It's also why there is cure for the common cold, also a corona virus that mutates very quickly.
So...on the WTAE/ABC affiliate the morning (this being the home of the world's best football team, the Steelers) they were talking football - specifically the Ravens...and how it had been reported that there were FOUR DIFFERENT STRAINS OF THE COVID 19 IN THEIR LOCKER ROOM/STAFF LAST WEEK.
Yes FOUR.
SO....is this vaccine gonna work? How is it working on 4 mutations? How is it 90% effective when NO flu vaccine is that good?
And add to this, on CBS news today was a story about 102 year old woman in NYC that has recoverd from COVID TWICE - so that means OBVIOUSLY there are questions about immunity...do you get it at all? FOr one strain only? It doesn't last?
I guess we all need to go into some form of online shopping/delivery....seems that will be a growth area for some time to come.
Surprisingly PA was VERY proactive, um, over re-active in the beginning of this - the latest surge (12,000 plus per day testing positive, testing rates of 37% postitive (goal is what, 5%?) and NOTHING from teh state health or governor. No lockdowns, no reduced capacity, etc.
And Ohio's infinite idiots say yes, school wresting may happen - AS LONG AS THE KIDS DON"T SHAKE HANDS it will be fine. WTF?
With bright minds saying things like that is it any wonder we have no clue what the reality is?
The flu vaccine is either trivalent or quadrivalent, so it's a cocktail that covers 3 or 4 strains, which change each year to use those calculated as most likely to circulate. So yes, it's possible a mutation isn't covered, but the probability is lower.
I'm going to assume over time that the CV-19 vaccine will do the same, but early versions will probably be based on a single strain. The vaccine should work on the other strains, just not as effectively. Nothing is perfect ..
Like the flu, Covid can be deadly to people who already have underlying conditions known or unknown at the time.
But it's transmission rate is faster and wider than the average flu. I'd like some definitive word on whether this is natural or a man-made variation of a novel Corona virus. It seems a little convenient that an oppressive Communist country with an overwhelming elderly population just happens to be the emergent source of a virus the fatality of which is so uniquely tailored to age and health issues.
But it's transmission rate is faster and wider than the average flu. I'd like some definitive word on whether this is natural or a man-made variation of a novel Corona virus. It seems a little convenient that an oppressive Communist country with an overwhelming elderly population just happens to be the emergent source of a virus the fatality of which is so uniquely tailored to age and health issues.
Actually China has an average age younger than the USA 37 compared to 37.9. They have many more old people because their population is much higher but are younger per capita. They also have MANY less deaths per capita than most of the world. They also use masks on a daily basis regardless if there is a virus on the go or not
Well .. since they seem to be accidentally releasing a new virus on a continuous basis .. makes sense.
Well .. since they seem to be accidentally releasing a new virus on a continuous basis .. makes sense.
It may be population control and it may be for world dominance I don't know I don't really subscribe to conspiracy theories much but I have a theory of my own
The one thing that stands out in the USA as a traveler is how crowded everything is. Go to Times Square any day a Million or more people are within relatively a few blocks of you roughly 380,000 go through Times square every day. New York is the best example but it's crammed in in most major cities
China has over 1.4 Billion people in a space roughly the size of the USA and like the USA the majority live in relation to cities. Imagine putting 3.5X the people in Times Square daily...That's living in China. Also like NYC it's not just Chinese living in China people from all over the world are on the streets on a daily basis.
People are germ bags and when similar viruses from around the world meet and mutate bad things happen. The spreading is easy just hit a major city things spread like wildfire
We have had warnings of this for decades. I remember being a kid and watching the news with my Grandfather and seeing about how bacteria were becoming immune to antibiotics and they were creating super drugs to fight certain infections and that was before the days of people going for pills every time we get a scratch
Now we have a new and exciting problem these high level twits that refuse to take their kids to be vaccinated for the basics things like Polio and Rubella etc. You can argue it but the fact is we had Polio they created a vaccine and in the Western world it's a thing of the past or at least it was....
None of this has anything to do with the maintenance cost of an elderly population under a socialist system where "Per capita" has no real meaning.
Under socialism you are a producer or not - which is why in it's most extreme state it often leads to mass murder.
My own kids and I happen to have been vaccinated, but here's the problem with your elitist comments on vaccination:
If you're going to ban peanut butter sandwiches from schools because there might be a few (unsubstantiated) kids who are seriously allergic - how then do you rationalize the forced exposure upon the few (unsubstantiated) kids who may be killed or permanently disabled by a vaccine?
In the first instance: the needs of the few trample the rights of the many.
In the second: the needs of the many trample the rights of the few.
Liberty is not convenient, and double standards are not acceptable in a free society.
Last edited:
With vaccines finally getting significant numbers, I'm hoping the end to pandemic is finally in sight.
Hopefully this summer things get (somewhat) back to normal.
So probably good time to get marketing back in gear.
Hopefully this summer things get (somewhat) back to normal.
So probably good time to get marketing back in gear.
I am waiting until after I do my first few weddings of 2021 which are scheduled in June at this point. After that, I will look more deeply at paid marketing for 2022 weddings.
I really don't know how I want to go about it moving forward. Part of me wants to sit back, and let the business just be a side income, and take whatever gigs come my way, and not worry about growth or making as much money as I can try to make as a DJ moving forward. I kind of feel like I have been there, and done that, and know what I can get out of the market at this point I may just start looking at being a DJ as an ingredient in a Bowl of multiple ingredients that I use to earn a living, and not look at it as my life, and Main focus of how I earn my income.
I’ve closed up my DJ business. It was always different for me than it was for you, but I think I understand your thinking. However, I took another route than most DJ’s, primarily because I was not good enough in the beginning to compete head on with other DJ’s, but also because I was already old BEFORE I started. I needed a niche (or two) that the better DJ’s would have no interest in. I never talked about it much on this forum, because other DJ’s in this area might be on the forum too, but I can talk about it now, since I’m off the market.
My first niche was Christian/Church events. I already had a big collection of Christian Rock music, so it wasn’t a stretch. I just contacted the Youth Director at a number of Churches in the vicinity (and there’s a BUNCH), and gave them my contact info. Granted, most churches don’t have a lot of money for music events, so they could not pay what you might get for a class reunion, or a corporate party. That was OK by me, since other DJ’s would not consider working for small groups and small $$$. I needed the work and the practice.
I also did fund raisers, and that was much more lucrative. People don’t know that most fund raising events have pretty big budgets. If they like you and trust you, they pay really well. I could also MC, so that contributed to my success as well. With some charity fund raisers, my competition was NOT other DJ’s. It was Jazz combo’s and such. However, if they wanted a good MC, the musicians were rarely any competition for me. The political fund raisers were easier. Bands were sometimes competing with me for gigs, but most could not play the variety of music I could offer, nor could they MC. Now... I had MANY friends who were elected state officials, and THEY all knew others they could refer me to, so it was easy getting started. I just had to do one event to show what I could do, and it snow-balled from there. I turned down more events than I did because I did not want to work EVERY weekend during election season. At most of these political fund raisers, there was a cocktail hour, adinner, speeches, then dancing, interspersed with announcements. Music would run the gamut from subdued, to patriotic, to Pop, big band, country, salsa... you name it. They were easy and fun and paid great! The best way to get started if you don’t know any elected politicians... go contact the campaign of some politician in your area. First termers are often more open to entertainment options, like a DJ than politicians who have been through numerous elections and already have a team of people they like. Dress elegantly. Appearance is 90% of everything.
You can’t come right out and say so, but you need to make it understood that you can be trusted to keep anything you see or hear to yourself.I did quite a few corporate parties, and other private events too (most often for someone who attended one of the fund raisers and saw me, or someone who saw me and referred me to them), but I never had to spend much money on marketing. Just food for thought for someone looking to market themselves in a very different way, for a much different kind of event.
Last edited:
I've sent two contracts for 2022 weddings so far this week, and I have another call scheduled on Saturday. The uptick for me in inquiries could be coincidence of when planners send people my way. But I'm getting the sense that dates are being snatched aggressively right now.
I think consumer confidence is pretty high right now, and I would absolutely be advertising if I needed to be.
I think consumer confidence is pretty high right now, and I would absolutely be advertising if I needed to be.
I think Consumer Confidence will be VERY HIGH all around as we approach Memorial Day weekend. Mother's Day will be the big test for food and beverage/restaurants. We will see how many families head out there year and pack the restaurants. Restaurants that are not fully staffed next weekend are going to be in for a world of hurt, and losing thousands of dollars in sales. If it looks like everyone across the country is out and spending money that weekend, that will be a big indicator of how this summer will go. Next big test is how busy beaches and resort areas get on Memorial Day weekend. If both tests prove to be successful and big sales then that is a sure sign that wedding bookings should be off the hook this summer/fall for 2022